Progressive supranuclear palsy (PSP), also known as the Steele-Richardson- Olszewski syndrome, is a tauopathy and considered a neurodegenerative disease. La parálisis supranuclear progresiva o síndrome Steele-Richardson-Olszewsky, es una enfermedad rara, degenerativa, producida por el deterioro y muerte. PDF | Summary Introduction: Progressive supranuclear palsy (PSP) is the second most common parkinsonism. Vertical gaze palsy and postural instability with.

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Disease Profile and Rehabilitation Strategies”. Two studies have suggested that rivastigmine may help with cognitive aspects, but the authors of both studies have suggested a larger sampling be used. These signs and symptoms worsen as the disease advances, and may include:.

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J Neurol Neurosurg Psychiatry. Because the eyes have trouble coming together to focus at short distances, the patient may complain of diplopia double vision when reading. J Neuropathol Exp Neurol. To avoid injuries due to falling, a walker or a wheelchair may be used.

Mayo Clinic Marketplace Check out these best-sellers and special offers on parqlisis and newsletters from Mayo Paralisjs. Mayo Clinic, Rochester, Minn. National Institute of Neurological Disorders and Stroke. Main anatomical planes and axes applied to the sections of the brain. Unlike globose NFTs, they may be more widespread in the cortex. Progressive supranuclear palsy care at Mayo Clinic. Due to the progressive supranhclear of this disease, all individuals eventually lose their ability to walk and will need to progress to using a wheelchair.


MRI features include The condition typically affects people around the age of 60, and is virtually unknown in people under the age of Falls in spranuclear elderly are common, dangerous and often disabling. Involuntary eye movement, as elicited by Bell’s phenomenonfor instance, may be closer to normal. Edit article Share article View revision history. Unable to process the form.

Notably, the ophthalmoparesis experienced by these patients mainly concerns voluntary eye movement and the inability to make vertical saccadeswhich is often worse with downward saccades.

Progressive supranuclear palsy – Wikipedia

Synonyms or Alternate Spellings: Request an Appointment at Mayo Clinic. Owens E, et al. It has been described as a tauopathy.

Progressive supranuclear palsy worsens over supranulcear and can lead to life-threatening complications, such as pneumonia and swallowing problems. Related Radiopaedia articles Neurodegenerative diseases Neurodegenerative diseases are legion and their classification just as protean. Patients with PSP usually seek or are referred to occupational therapyspeech-language pathology for motor speech changes typically a spastic-ataxic dysarthria, and physical therapy for balance and gait problems with reports of frequent falls.

Clumps of tau oaralisis also characteristic of other neurodegenerative disorders, such as Alzheimer’s disease. Speech pqralisis reflect differing pathophysiology in Parkinson’s disease, progressive supranuclear palsy and multiple system atrophy. Magnetic resonance imaging; parkinsonian disorders; recurrent falls; supranuclear palsy progressive MeSH. Recent patents on CNS drug discovery. Uses authors parameter CS1 maint: This vertical gaze paresis will correct when the examiner passively rolls the patient’s head up and down as part of a test for the oculocephalic reflex.


Although certain features help in favouring PSP over alternative clinical diagnoses Parkinson disease and multiple system atrophy for example it should be noted that except in classical cases, imaging features can usually at most be suggestive of the diagnosis rather than paralisiz, as there is overlap with other conditions. Later symptoms and signs are dementia typically including loss of inhibition and ability to organize informationslurring of speechdifficulty swallowingand difficulty moving the eyesparticularly in the vertical direction.

Articles Cases Courses Quiz. Pneumonia is a frequent cause of death. Key emerging issues in progressive supranuclear palsy and corticobasal degeneration.

Progressive supranuclear palsy

These include signal increase and atrophy of the midbrain, thinning or smudging of the substantia nigra, atrophy of the putamen, atrophy and signal increase of globus pallidus.

Mayo Foundation for Medical Education and Research; Fukui Y, et al. About Blog Go ad-free.

The cause of PSP is unknown.