Lupus miliaris disseminatus faciei (LMDF) is a granulomatous eruption characterized by monomorphic, reddish-brown papules and nodules predominantly. A biopsy specimen revealed epithelioid cell granulomas with central necrosis, consistent with a diagnosis of lupus miliaris disseminatus faciei (Figure 2). Lupus miliaris disseminatus faciei (LMDF) first described in is an uncommon dermatosis of unknown etiology with characteristic.

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Andrews’ Diseases of the Skin. The exact etiopathogenesis of LMDF remains unknown.

Lupus miliaris disseminatus faciei successfully treated with tranilast: He works in biscuit wrapper manufacturing unit; but there is no history of contact with any chemical or fumes. Select your language of interest to view the total content facoei your interested language.

Lupus miliaris disseminatus faciei pathology | DermNet NZ

Biopsy from a representative skin nodule showed mild epidermal hyperplasia and granulomatous reaction pattern in the dermis. Age y Sex Site Lesion No. The early lesions are characterized by superficial perivascular and periappendageal infiltrates composed primarily of lymphocytes with a few histiocytes and neutrophils. Improvement in lesions after dapsone therapy Click here to view. A final diagnosis of lupus miliaris disseminatus faciei was made based on the above-mentioned features.

Get free access to newly published articles. The presence of nuclear dust and neutrophils within the zones of caseation necrosis suggests that neutrophils may indeed play a role in inducing this change [ 9 ].

Lupus miliaris disseminatus faciei pathology

Histopathological examination of a skin biopsy taken from a representative lesion on the chin revealed dermal epithelioid cell granulomas, some with central areas of necrosis, and surrounding moderate lymphohistiocytic infiltrate with multinucleate giant cells, mostly of the Langhans type Figure 2. Spontaneous resolution of the lesions is reported to occur over years, often leaving small, pitted scars [ 156 ].


Scarring of lupus miliaris disseminatus faciei: None, Mipiaris of Interest: No recurrence was noted over a month observation period. Guidelines Upcoming Special Issues. Granulomatous rosacea, mucinosis, intradermal nevus, actinic keratosis, and deep molluscum were listed as clinical differential diagnoses in one case each Table 1.


There are a number of possible mechanisms by which the nm diode laser can improve lupus miliaris disseminatus faciei. Histologic spectrum of LMDF. Puppin D Jr, Gueissaz F. The following report describes the clinical and histopathologic findings in 10 cases of LMDF seen in our institution over a year period. Extrafacial involvement in LMDF has been rarely reported in the literature. A name change to facial idiopathic granulomas with regressive evolution Diaseminatus was proposed inmilairis this nomenclature does not appear to have been widely accepted facifi date.

B, Resolution of papules after 3 treatments with the laser. Therapy is disseminatuus with variable efficacy and several therapeutic modalities, e. Get free access to newly published articles Create a personal account or sign in to: If the broader histopathologic definitions of LMDF were to be considered, distinguishing between these two entities would prove to be challenging.

Granulomatous syphilisdeep fungal infectionleishmaniasistuberculosis — PCR and culture studies may be needed for the distinction in difficult cases. Sign in to save your search Sign in to your personal account. In seven of the cases, a perifollicular distribution of the granulomas was noted Dissemintaus 2.

The inflammatory lesions are located on the face, where the density of pilosebaceous units is highest. To prevent diagnostic confusion, we advocate limiting the histologic criteria to include only fully developed lesions demonstrating epithelioid granulomas with caseous necrosis [ 17 ].

Some authors consider it to be a variant of granulomatous rosacea, 1 – 4 while others believe that it is a distinct clinical entity.

By 16 weeks, a moderate improvement had been achieved, despite the residual depressed scars, and minocycline was tapered to mg every other day and prednisolone to 5 mg every other day, which she maintained for an additional eight weeks Figure 3. Find articles by Helena Toda-Brito.


This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike facii. Lymphocytes were seen in eight cases Figure ; the lymphocytes formed an outer layer surrounding the granuloma in four cases Figure 3.

LMDF typically occurs as symmetrically distributed eruptions in the center of the face.

Red papules on the face with secondary scarring. Sarcoidosis is considered to be a cell mediated granulomatous disease. Copyright American Medical Association. Axillary acne agminata lupus miliaris diiseminatus faciei Clin Exp Dermatol. Fully developed lesions typically demonstrate perifollicular epithelioid granulomas, sometimes with follicular rupture. Clinically, it is characterized by an asymptomatic papular eruption mainly involving the central face, typically on and around the eyelids.

Lupus miliaris disseminatus faciei Miliagisfirst described by Fox inis a rare granulomatous inflammatory dermatosis that mostly affects young adults.

Multiple, small, reddish-brown papules scattered over the forehead, eyelids, nose, cheeks, perioral area, and chin.

June 28, ; Published date: Report of a case. His wife was treated 6 months treatment for tuberculous lymphadenitis a year back; but he himself never had cough, expectoration, hemoptysis, or weight loss.

One case report described LMDF without any facial involvement; the papules were located on the neck and chest only [ 7 ]. The lesions initially appeared on the chin and left side of the neck, which progressively involved his forehead, both the cheeks, earlobes, upper eyelids, and whole of his neck over a period of 2 months.